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KMID : 0882420100790020163
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Korean Journal of Medicine
2010 Volume.79 No. 2 p.163 ~ p.170
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Association of serum osteoprotegerin with coronary artery calcification scores in patients with asymptomatic type 2 diabetes
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Cho Eun-Hee
Lee Dong-Gyu
Kim Sang-Wook
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Abstract
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Background/Aims: Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, is involved in bone metabolism and vascular calcification. However, the relationship between serum OPG levels and coronary calcification is not well elucidated. The present study investigated whether serum OPG levels are associated with coronary artery calcification scores (CACs) in patients with type 2 diabetes.
Methods: A total of 140 type 2 diabetic outpatients without previous evidence of clinical cardiovascular disease were recruited. CACs were obtained using multi-slice spiral computed tomography and categorized as minimal (0), mild (1-99), moderate (100-399), or severe (≥ 400). Serum OPG levels were measured by enzyme-linked immunosorbent assay.
Results: A total of 94 of 140 (67.1%) patients with type 2 diabetes showed coronary calcification. A Pearson’s correlation analysis showed a positive correlation between serum OPG levels and CACs. However, multivariate regression analyses revealed that waist circumference, duration of diabetes, and serum creatinine concentration were significant independent determinants of CACs.
Conclusions: The present study demonstrates that coronary calcification is common (67.1%), and serum OPG levels are correlated with CACs but are not an independent determinant of CACs in patients with asymptomatic type 2 diabetes.
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KEYWORD
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Osteoprotegerin, Coronary artery, Calcification, Diabetes mellitus
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